Fourth case of Clade I monkeypox detected in U.S., health officials say

ATLANTA — The United States has confirmed a fourth case of clade I mpox, with the New York State Department of Health reporting the latest infection in February, health officials announced.

The first U.S. case of clade I mpox was detected in November 2024, followed by cases in Georgia in January 2025 and New Hampshire earlier this month. No additional cases have been reported, and health officials say the infections are not linked.

All four individuals had recently traveled from regions experiencing clade I mpox outbreaks and sought medical care for symptoms after arriving in the U.S., according to the Centers for Disease Control and Prevention (CDC).

The CDC continues to assess the risk of clade I mpox, which is spreading in Central and Eastern Africa, but has not issued any new health alerts.